Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

Communication Bandwidth Prediction Technology for Smart Power Distribution Business in Smart Parks

Accurate prediction of power business communication bandwidth is the premise for the effectiveness of power communication planning and the fundamental guarantee for regular operation of power businesses. To solve the problem of scientifically and reasonably allocating bandwidth resources in smart parks, communication bandwidth prediction technology of intelligent power distribution service for smart parks is proposed in this paper. First, the characteristics of mixed service data arrival rate of power distribution and communication mixed services in smart parks were analyzed. Poisson process and interrupted Poisson process were used to simulate periodic and sudden business of smart parks to realize accurate simulation of the business arrival process. Then, a service arrival rate model based on the Markov modulation Poisson process was constructed. An active buffer management mechanism was used to dynamically discard data packets according to the set threshold and achieve accurate simulation of the packet loss rate during the arrival of smart park business. At the same time, considering the communication service quality index and bandwidth resource utilization, a business communication bandwidth prediction model of smart parks was established to improve the accuracy of business bandwidth prediction. Finally, a smart power distribution room in a smart park was used as an application scenario to quantitatively analyze the relationship between the communication service quality and bandwidth configuration. According to the predicted bandwidth, the reliability and effectiveness of the proposed method were verified by comparison with the elastic coefficient method

Communication Bandwidth Prediction Technology for Smart Power Distribution Business in Smart Parks

Accurate prediction of power business communication bandwidth is the premise for the effectiveness of power communication planning and the fundamental guarantee for regular operation of power businesses. To solve the problem of scientifically and reasonably allocating bandwidth resources in smart parks, communication bandwidth prediction technology of intelligent power distribution service for smart parks is proposed in this paper. First, the characteristics of mixed service data arrival rate of power distribution and communication mixed services in smart parks were analyzed. Poisson process and interrupted Poisson process were used to simulate periodic and sudden business of smart parks to realize accurate simulation of the business arrival process. Then, a service arrival rate model based on the Markov modulation Poisson process was constructed. An active buffer management mechanism was used to dynamically discard data packets according to the set threshold and achieve accurate simulation of the packet loss rate during the arrival of smart park business. At the same time, considering the communication service quality index and bandwidth resource utilization, a business communication bandwidth prediction model of smart parks was established to improve the accuracy of business bandwidth prediction. Finally, a smart power distribution room in a smart park was used as an application scenario to quantitatively analyze the relationship between the communication service quality and bandwidth configuration. According to the predicted bandwidth, the reliability and effectiveness of the proposed method were verified by comparison with the elastic coefficient method